Drug interactions
Brexpiprazole + Risperidone
Severity: Moderate
Brexpiprazole and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are atypical antipsychotics, and using them together adds to sedation, orthostatic hypotension, extrapyramidal symptoms, hyperprolactinaemia and metabolic effects. Brexpiprazole is a partial D2 agonist, so mixing it with a full antagonist offers unclear benefit.
What this interaction means in plain words
Brexpiprazole and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Risperidone belongs to Central Nervous System.
Why it happens
Additive dopamine D2 and serotonin receptor effects, with overlapping alpha-adrenergic and histaminergic blockade.
What to do
Avoid routine combination and use the lowest effective doses if it is needed. Monitor for extrapyramidal symptoms, sedation, blood pressure and metabolic parameters.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Brexpiprazole with Risperidone?
MediHelp rates the interaction as moderate. Brexpiprazole and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are atypical antipsychotics, and using them together adds to sedation, orthostatic hypotension, extrapyramidal symptoms, hyperprolactinaemia and metabolic effects. Brexpiprazole is a partial D2 agonist, so mixing it with a full antagonist offers unclear benefit.
How serious is the interaction between Brexpiprazole and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combination and use the lowest effective doses if it is needed. Monitor for extrapyramidal symptoms, sedation, blood pressure and metabolic parameters.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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