Drug interactions
Brexpiprazole + Rucaparib
Severity: Minor
Brexpiprazole and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak to moderate CYP3A4 inhibitor and may modestly increase brexpiprazole levels. The clinical effect is probably small but could raise dose-related adverse effects such as sedation or akathisia.
What this interaction means in plain words
Brexpiprazole and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brexpiprazole belongs to Central Nervous System; Rucaparib belongs to Oncology.
Why it happens
Rucaparib inhibits CYP3A4, reducing brexpiprazole metabolism.
What to do
No routine dose change is required; monitor for sedation, akathisia and orthostasis, and reduce the brexpiprazole dose if adverse effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Brexpiprazole
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Brexpiprazole with Rucaparib?
MediHelp rates the interaction as minor. Brexpiprazole and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a weak to moderate CYP3A4 inhibitor and may modestly increase brexpiprazole levels. The clinical effect is probably small but could raise dose-related adverse effects such as sedation or akathisia.
How serious is the interaction between Brexpiprazole and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is required; monitor for sedation, akathisia and orthostasis, and reduce the brexpiprazole dose if adverse effects emerge.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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