Drug interactions
Brexpiprazole + Tramadol
Severity: Moderate
Brexpiprazole and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation and dizziness, so combined use may reduce alertness and impair psychomotor performance. Brexpiprazole is metabolized by CYP2D6 and CYP3A4, and tramadol may lower seizure threshold.
What this interaction means in plain words
Brexpiprazole and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Tramadol belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for excess sedation, orthostasis and seizures, particularly during dose changes. Counsel patients on driving and machinery use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Tramadol?
MediHelp rates the interaction as moderate. Brexpiprazole and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation and dizziness, so combined use may reduce alertness and impair psychomotor performance. Brexpiprazole is metabolized by CYP2D6 and CYP3A4, and tramadol may lower seizure threshold.
How serious is the interaction between Brexpiprazole and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation, orthostasis and seizures, particularly during dose changes. Counsel patients on driving and machinery use.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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