Drug interactions
Brexpiprazole + Zileuton
Severity: Minor
Brexpiprazole and Zileuton: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zileuton is a CYP1A2 inhibitor with little CYP3A4 effect, so a meaningful rise in brexpiprazole exposure is not established. The legacy dose-reduction advice applies to moderate CYP3A4 inhibitors given with CYP2D6 inhibitors, not clearly to zileuton.
What this interaction means in plain words
Brexpiprazole and Zileuton have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brexpiprazole belongs to Central Nervous System; Zileuton belongs to Respiratory.
Why it happens
Zileuton has only weak or uncertain CYP3A4 inhibition; any effect on brexpiprazole is theoretical.
What to do
No empiric dose change is needed. Monitor for brexpiprazole adverse effects such as akathisia, sedation and weight gain, especially if a CYP2D6 inhibitor is also used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Zileuton?
MediHelp rates the interaction as minor. Brexpiprazole and Zileuton have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zileuton is a CYP1A2 inhibitor with little CYP3A4 effect, so a meaningful rise in brexpiprazole exposure is not established. The legacy dose-reduction advice applies to moderate CYP3A4 inhibitors given with CYP2D6 inhibitors, not clearly to zileuton.
How serious is the interaction between Brexpiprazole and Zileuton?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed. Monitor for brexpiprazole adverse effects such as akathisia, sedation and weight gain, especially if a CYP2D6 inhibitor is also used.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Zileuton page.
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