Drug interactions
Brigatinib + Colchicine
Severity: Minor
Brigatinib and Colchicine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brigatinib may induce CYP3A4 in vitro, which could lower colchicine exposure and reduce efficacy. The clinical significance is uncertain and there is no clear evidence of harm.
What this interaction means in plain words
Brigatinib and Colchicine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brigatinib belongs to Oncology; Colchicine belongs to Genitourinary.
Why it happens
Possible CYP3A4 induction by brigatinib, based mainly on in vitro data.
What to do
Monitor for reduced colchicine efficacy, such as recurrent gout flares, and adjust the dose to clinical response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Other interactions of Brigatinib
Frequently asked questions
Can I take Brigatinib with Colchicine?
MediHelp rates the interaction as minor. Brigatinib and Colchicine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brigatinib may induce CYP3A4 in vitro, which could lower colchicine exposure and reduce efficacy. The clinical significance is uncertain and there is no clear evidence of harm.
How serious is the interaction between Brigatinib and Colchicine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced colchicine efficacy, such as recurrent gout flares, and adjust the dose to clinical response.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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