Drug interactions
Brigatinib + Ergotamine
Severity: Moderate
Brigatinib and Ergotamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brigatinib may induce CYP3A4 and lower ergotamine concentrations, reducing migraine efficacy. The loss of effect is the main concern and may prompt dose escalation.
What this interaction means in plain words
Brigatinib and Ergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brigatinib belongs to Oncology; Ergotamine belongs to Central Nervous System.
Why it happens
Brigatinib induces CYP3A4, increasing ergotamine metabolism.
What to do
Monitor for reduced headache response and avoid raising ergotamine beyond labeled limits. Consider a non-CYP3A4 migraine alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Other interactions of Brigatinib
Frequently asked questions
Can I take Brigatinib with Ergotamine?
MediHelp rates the interaction as moderate. Brigatinib and Ergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brigatinib may induce CYP3A4 and lower ergotamine concentrations, reducing migraine efficacy. The loss of effect is the main concern and may prompt dose escalation.
How serious is the interaction between Brigatinib and Ergotamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced headache response and avoid raising ergotamine beyond labeled limits. Consider a non-CYP3A4 migraine alternative.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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