Drug interactions
Brigatinib + Everolimus
Severity: Moderate
Brigatinib and Everolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brigatinib induces CYP3A4 in vitro and may lower everolimus concentrations. Reduced exposure could weaken antitumor or antirejection efficacy.
What this interaction means in plain words
Brigatinib and Everolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brigatinib belongs to Oncology; Everolimus belongs to Oncology.
Why it happens
Induction of CYP3A4 by brigatinib, increasing everolimus clearance.
What to do
Monitor for loss of efficacy, and check everolimus trough concentrations in transplant patients, adjusting the dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Other interactions of Brigatinib
Frequently asked questions
Can I take Brigatinib with Everolimus?
MediHelp rates the interaction as moderate. Brigatinib and Everolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brigatinib induces CYP3A4 in vitro and may lower everolimus concentrations. Reduced exposure could weaken antitumor or antirejection efficacy.
How serious is the interaction between Brigatinib and Everolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of efficacy, and check everolimus trough concentrations in transplant patients, adjusting the dose as needed.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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