Drug interactions
Brigatinib + Nevirapine
Severity: Major
Brigatinib and Nevirapine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may lower brigatinib exposure and reduce its antitumor effect.
What this interaction means in plain words
Brigatinib and Nevirapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Brigatinib belongs to Oncology; Nevirapine belongs to Anti Virals.
Why it happens
CYP3A4 induction by nevirapine increases brigatinib clearance.
What to do
Avoid coadministration. If a strong or moderate inducer is unavoidable, follow labeled dose adjustment and monitor tumor response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Brigatinib
Frequently asked questions
Can I take Brigatinib with Nevirapine?
MediHelp rates the interaction as major. Brigatinib and Nevirapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nevirapine may lower brigatinib exposure and reduce its antitumor effect.
How serious is the interaction between Brigatinib and Nevirapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration. If a strong or moderate inducer is unavoidable, follow labeled dose adjustment and monitor tumor response.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
Full monographs, dosing and an interaction checker in the MediHelp app
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