Drug interactions
Bromocriptine + Ceritinib
Severity: Moderate
Bromocriptine and Ceritinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib inhibits CYP3A4 and may increase bromocriptine exposure. Higher levels raise the risk of hypotension, nausea and other dopaminergic adverse effects.
What this interaction means in plain words
Bromocriptine and Ceritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bromocriptine belongs to Central Nervous System; Ceritinib belongs to Oncology.
Why it happens
Ceritinib inhibits CYP3A4, reducing the metabolism of bromocriptine.
What to do
Use a lower bromocriptine dose and monitor blood pressure and tolerability. Adjust the dose according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bromocriptine
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Bromocriptine with Ceritinib?
MediHelp rates the interaction as moderate. Bromocriptine and Ceritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib inhibits CYP3A4 and may increase bromocriptine exposure. Higher levels raise the risk of hypotension, nausea and other dopaminergic adverse effects.
How serious is the interaction between Bromocriptine and Ceritinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a lower bromocriptine dose and monitor blood pressure and tolerability. Adjust the dose according to response.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
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