Drug interactions
Bromocriptine + Erythromycin lactobionate
Severity: Moderate
Bromocriptine and Erythromycin lactobionate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin can raise bromocriptine concentrations, increasing dopaminergic adverse effects such as nausea, hypotension and dizziness. Case reports describe increased bromocriptine effects with macrolides.
What this interaction means in plain words
Bromocriptine and Erythromycin lactobionate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bromocriptine belongs to Central Nervous System; Erythromycin lactobionate belongs to Anti Bacterial.
Why it happens
Inhibition of CYP3A4-mediated bromocriptine metabolism by erythromycin.
What to do
Monitor for bromocriptine toxicity and consider reducing the dose during macrolide therapy. Consider azithromycin as an alternative antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bromocriptine
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Bromocriptine with Erythromycin lactobionate?
MediHelp rates the interaction as moderate. Bromocriptine and Erythromycin lactobionate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin can raise bromocriptine concentrations, increasing dopaminergic adverse effects such as nausea, hypotension and dizziness. Case reports describe increased bromocriptine effects with macrolides.
How serious is the interaction between Bromocriptine and Erythromycin lactobionate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bromocriptine toxicity and consider reducing the dose during macrolide therapy. Consider azithromycin as an alternative antibiotic.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
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