Drug interactions
Bromocriptine + Fedratinib
Severity: Moderate
Bromocriptine and Fedratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP3A4 inhibitor and may increase bromocriptine exposure. This could amplify nausea, hypotension and other dopaminergic effects.
What this interaction means in plain words
Bromocriptine and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bromocriptine belongs to Central Nervous System; Fedratinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated bromocriptine metabolism by fedratinib.
What to do
Monitor blood pressure and bromocriptine adverse effects, and reduce the bromocriptine dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bromocriptine
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Bromocriptine with Fedratinib?
MediHelp rates the interaction as moderate. Bromocriptine and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is a moderate CYP3A4 inhibitor and may increase bromocriptine exposure. This could amplify nausea, hypotension and other dopaminergic effects.
How serious is the interaction between Bromocriptine and Fedratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and bromocriptine adverse effects, and reduce the bromocriptine dose if they occur.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
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