Drug interactions

Bromocriptine + Idelalisib

Severity: Major

Bromocriptine and Idelalisib: major interaction.

Last updated 29 Oct 2026 Sources: US FDA label

For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

Idelalisib is a strong CYP3A inhibitor and can substantially increase bromocriptine exposure. This may lead to hypotension, syncope, nausea, confusion or hallucinations.

What this interaction means in plain words

Bromocriptine and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Bromocriptine belongs to Central Nervous System; Idelalisib belongs to Oncology.

Evidence level: Moderate

Why it happens

Strong inhibition of CYP3A4 reduces bromocriptine clearance.

What to do

Avoid concurrent use if possible; otherwise reduce the bromocriptine dose and monitor blood pressure and neuropsychiatric effects closely.

What to ask your pharmacist

Does the benefit of taking both outweigh the risk in my case?
Do I need any blood test, ECG or other check while on both?
What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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References

Bromocriptine Mesylate - FDA drug label (DailyMed) - section 7 Drug Interactions (class statement: strong CYP3A4 inhibitors; "Avoid concomitant use of bromocriptine mesylate with strong CYP3A4 inhibitors.") — DailyMed (FDA label)

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Alfuzosin + Idelalisib Contraindicated
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Dihydroergotamine + Idelalisib Contraindicated
Dronedarone + Idelalisib Contraindicated
Eletriptan + Idelalisib Contraindicated
Eplerenone + Idelalisib Contraindicated

Frequently asked questions

Can I take Bromocriptine with Idelalisib?

MediHelp rates the interaction as major. Bromocriptine and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Idelalisib is a strong CYP3A inhibitor and can substantially increase bromocriptine exposure. This may lead to hypotension, syncope, nausea, confusion or hallucinations.

How serious is the interaction between Bromocriptine and Idelalisib?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if possible; otherwise reduce the bromocriptine dose and monitor blood pressure and neuropsychiatric effects closely.

What other medicines interact with Bromocriptine?

MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.

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