Drug interactions
Bromocriptine + Midodrine
Severity: Moderate
Bromocriptine and Midodrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midodrine is an alpha-1 agonist that raises blood pressure, and bromocriptine can have vasoactive effects including rare hypertension. Combined use may produce excessive pressor responses.
What this interaction means in plain words
Bromocriptine and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bromocriptine belongs to Central Nervous System; Midodrine belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic vasopressor effects.
What to do
Monitor blood pressure, including supine readings, and adjust the midodrine dose if hypertension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bromocriptine
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Bromocriptine with Midodrine?
MediHelp rates the interaction as moderate. Bromocriptine and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midodrine is an alpha-1 agonist that raises blood pressure, and bromocriptine can have vasoactive effects including rare hypertension. Combined use may produce excessive pressor responses.
How serious is the interaction between Bromocriptine and Midodrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including supine readings, and adjust the midodrine dose if hypertension occurs.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
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