Drug interactions
Bromocriptine + Risperidone
Severity: Moderate
Bromocriptine and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone blocks D2 receptors and opposes the effect of bromocriptine. This can reduce the efficacy of bromocriptine in Parkinson disease, and in hyperprolactinemia.
What this interaction means in plain words
Bromocriptine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bromocriptine belongs to Central Nervous System; Risperidone belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at dopamine D2 receptors.
What to do
Avoid in Parkinson disease; if an antipsychotic is needed, use quetiapine or clozapine. Monitor prolactin and symptoms if used for hyperprolactinemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bromocriptine and Risperidone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Bromocriptine
Frequently asked questions
Can I take Bromocriptine with Risperidone?
MediHelp rates the interaction as moderate. Bromocriptine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone blocks D2 receptors and opposes the effect of bromocriptine. This can reduce the efficacy of bromocriptine in Parkinson disease, and in hyperprolactinemia.
How serious is the interaction between Bromocriptine and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in Parkinson disease; if an antipsychotic is needed, use quetiapine or clozapine. Monitor prolactin and symptoms if used for hyperprolactinemia.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
