Drug interactions
Bromocriptine + Rucaparib
Severity: Minor
Bromocriptine and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP3A4 weakly and could raise bromocriptine concentrations modestly. The result may be more dopaminergic adverse effects.
What this interaction means in plain words
Bromocriptine and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bromocriptine belongs to Central Nervous System; Rucaparib belongs to Oncology.
Why it happens
Rucaparib inhibits CYP3A4 metabolism of bromocriptine.
What to do
Monitor for nausea, dizziness and hypotension and reduce the bromocriptine dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bromocriptine
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Bromocriptine with Rucaparib?
MediHelp rates the interaction as minor. Bromocriptine and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib inhibits CYP3A4 weakly and could raise bromocriptine concentrations modestly. The result may be more dopaminergic adverse effects.
How serious is the interaction between Bromocriptine and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for nausea, dizziness and hypotension and reduce the bromocriptine dose if they occur.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
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