Drug interactions
Brompheniramine + Perampanel
Severity: Moderate
Brompheniramine and Perampanel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perampanel commonly causes dizziness, somnolence and impaired coordination, and brompheniramine adds sedation. Together they may increase drowsiness, psychomotor impairment and fall risk.
What this interaction means in plain words
Brompheniramine and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Perampanel belongs to Central Nervous System.
Why it happens
Additive central nervous system depression from AMPA-receptor antagonism and H1 blockade.
What to do
Counsel on drowsiness and avoid driving or hazardous tasks. Prefer a non-sedating antihistamine in patients taking perampanel.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Other interactions of Perampanel
- Apalutamide + Perampanel Major
- Enzalutamide + Perampanel Major
- Alprazolam + Perampanel Moderate
- Amisulpride + Perampanel Moderate
- Amobarbital + Perampanel Moderate
- Asenapine + Perampanel Moderate
Frequently asked questions
Can I take Brompheniramine with Perampanel?
MediHelp rates the interaction as moderate. Brompheniramine and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perampanel commonly causes dizziness, somnolence and impaired coordination, and brompheniramine adds sedation. Together they may increase drowsiness, psychomotor impairment and fall risk.
How serious is the interaction between Brompheniramine and Perampanel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on drowsiness and avoid driving or hazardous tasks. Prefer a non-sedating antihistamine in patients taking perampanel.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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