Drug interactions
Brompheniramine + Prochlorperazine
Severity: Moderate
Brompheniramine and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause sedation and have anticholinergic effects, so combined use increases drowsiness, dry mouth, urinary retention and confusion. Older adults are particularly vulnerable.
What this interaction means in plain words
Brompheniramine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive CNS depression and anticholinergic effects through H1 and muscarinic receptor blockade.
What to do
Avoid driving and alcohol, and monitor older patients for confusion and urinary retention; consider a non-sedating antihistamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Prochlorperazine?
MediHelp rates the interaction as moderate. Brompheniramine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents cause sedation and have anticholinergic effects, so combined use increases drowsiness, dry mouth, urinary retention and confusion. Older adults are particularly vulnerable.
How serious is the interaction between Brompheniramine and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid driving and alcohol, and monitor older patients for confusion and urinary retention; consider a non-sedating antihistamine.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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