Drug interactions
Budesonide-formoterol + Chlorpromazine
Severity: Major
Budesonide-formoterol and Chlorpromazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine prolongs the QT interval and formoterol can add to this effect while also causing hypokalemia and tachycardia. Together they may raise the risk of torsades de pointes, especially in patients with other risk factors.
What this interaction means in plain words
Budesonide-formoterol and Chlorpromazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Budesonide-formoterol belongs to Respiratory; Chlorpromazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with beta-agonist-induced hypokalemia adding to the arrhythmic risk.
What to do
Check ECG and serum potassium and magnesium before and during co-therapy. Use an alternative bronchodilator or antipsychotic if QTc becomes prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Budesonide-formoterol
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Budesonide-formoterol with Chlorpromazine?
MediHelp rates the interaction as major. Budesonide-formoterol and Chlorpromazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chlorpromazine prolongs the QT interval and formoterol can add to this effect while also causing hypokalemia and tachycardia. Together they may raise the risk of torsades de pointes, especially in patients with other risk factors.
How serious is the interaction between Budesonide-formoterol and Chlorpromazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and serum potassium and magnesium before and during co-therapy. Use an alternative bronchodilator or antipsychotic if QTc becomes prolonged.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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