Drug interactions
Budesonide-formoterol + Disopyramide
Severity: Major
Budesonide-formoterol and Disopyramide: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disopyramide prolongs the QT interval and can cause torsades de pointes, and formoterol may add to this and lower potassium. The combination raises arrhythmia risk.
What this interaction means in plain words
Budesonide-formoterol and Disopyramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Budesonide-formoterol belongs to Respiratory; Disopyramide belongs to Cardiovascular.
Why it happens
Additive QT prolongation and beta-2 agonist-induced hypokalemia.
What to do
Avoid if possible; otherwise monitor ECG and correct potassium and magnesium. Consider alternatives.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Budesonide-formoterol
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Budesonide-formoterol with Disopyramide?
MediHelp rates the interaction as major. Budesonide-formoterol and Disopyramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Disopyramide prolongs the QT interval and can cause torsades de pointes, and formoterol may add to this and lower potassium. The combination raises arrhythmia risk.
How serious is the interaction between Budesonide-formoterol and Disopyramide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor ECG and correct potassium and magnesium. Consider alternatives.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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