Drug interactions
Budesonide-formoterol + Pentamidine
Severity: Major
Budesonide-formoterol and Pentamidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic pentamidine can cause QT prolongation and torsades de pointes, and formoterol may add to this risk and lower potassium. Pentamidine can also cause hypoglycemia and electrolyte disturbance.
What this interaction means in plain words
Budesonide-formoterol and Pentamidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Budesonide-formoterol belongs to Respiratory; Pentamidine belongs to Anti Parasitic.
Why it happens
Additive QTc prolongation, with beta-agonist induced hypokalemia.
What to do
Avoid if possible; otherwise monitor ECG, potassium and magnesium during pentamidine therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Budesonide-formoterol
Other interactions of Pentamidine
- Clomipramine + Pentamidine Contraindicated
- Desipramine + Pentamidine Contraindicated
- Dronedarone + Pentamidine Contraindicated
- Moxifloxacin + Pentamidine Contraindicated
- Nortriptyline + Pentamidine Contraindicated
- Pentamidine + Pimozide Contraindicated
Frequently asked questions
Can I take Budesonide-formoterol with Pentamidine?
MediHelp rates the interaction as major. Budesonide-formoterol and Pentamidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Systemic pentamidine can cause QT prolongation and torsades de pointes, and formoterol may add to this risk and lower potassium. Pentamidine can also cause hypoglycemia and electrolyte disturbance.
How serious is the interaction between Budesonide-formoterol and Pentamidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor ECG, potassium and magnesium during pentamidine therapy.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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