Drug interactions
Bumetanide + Ethinyl estradiol-drospirenone
Severity: Minor
Bumetanide and Ethinyl estradiol-drospirenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone tends to retain potassium, whereas bumetanide, a loop diuretic, promotes urinary potassium loss. The two effects oppose each other, so the net change is unpredictable and hyperkalemia is unlikely.
What this interaction means in plain words
Bumetanide and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bumetanide belongs to Cardiovascular; Ethinyl estradiol-drospirenone belongs to Endocrine.
Why it happens
Opposing effects on potassium: aldosterone antagonism by drospirenone versus increased renal potassium excretion by the loop diuretic.
What to do
Check serum potassium when starting the combination in patients with renal disease or heart failure. No dose change is needed routinely.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Ethinyl estradiol-drospirenone?
MediHelp rates the interaction as minor. Bumetanide and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone tends to retain potassium, whereas bumetanide, a loop diuretic, promotes urinary potassium loss. The two effects oppose each other, so the net change is unpredictable and hyperkalemia is unlikely.
How serious is the interaction between Bumetanide and Ethinyl estradiol-drospirenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium when starting the combination in patients with renal disease or heart failure. No dose change is needed routinely.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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