Drug interactions
Bumetanide + Gentamicin
Severity: Major
Bumetanide and Gentamicin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bumetanide used with gentamicin increases the chance of cochlear and vestibular toxicity and of acute kidney injury. Hearing loss can be irreversible and is more likely with high doses, renal impairment or dehydration.
What this interaction means in plain words
Bumetanide and Gentamicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bumetanide belongs to Cardiovascular; Gentamicin belongs to Anti Bacterial.
Why it happens
Additive ototoxicity and nephrotoxicity, with diuretic-related volume depletion raising aminoglycoside exposure.
What to do
Avoid if possible; otherwise correct volume status, use the lowest effective doses, and monitor serum creatinine, gentamicin concentrations and auditory function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bumetanide and Gentamicin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Gentamicin?
MediHelp rates the interaction as major. Bumetanide and Gentamicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bumetanide used with gentamicin increases the chance of cochlear and vestibular toxicity and of acute kidney injury. Hearing loss can be irreversible and is more likely with high doses, renal impairment or dehydration.
How serious is the interaction between Bumetanide and Gentamicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise correct volume status, use the lowest effective doses, and monitor serum creatinine, gentamicin concentrations and auditory function.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
