Drug interactions
Bumetanide + Hydrochlorothiazide-lisinopril
Severity: Moderate
Bumetanide and Hydrochlorothiazide-lisinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a loop diuretic with a thiazide produces a strong sequential nephron blockade and can cause marked diuresis, volume depletion, hypokalemia, hyponatremia and hypomagnesemia. With an ACE inhibitor, hypotension and renal impairment are more likely.
What this interaction means in plain words
Bumetanide and Hydrochlorothiazide-lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Hydrochlorothiazide-lisinopril belongs to Cardiovascular.
Why it happens
Additive diuresis and electrolyte loss from blockade of the loop of Henle and distal tubule.
What to do
Monitor electrolytes, renal function, weight and blood pressure, especially in the first weeks. Reduce diuretic doses if volume depletion develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as moderate. Bumetanide and Hydrochlorothiazide-lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a loop diuretic with a thiazide produces a strong sequential nephron blockade and can cause marked diuresis, volume depletion, hypokalemia, hyponatremia and hypomagnesemia. With an ACE inhibitor, hypotension and renal impairment are more likely.
How serious is the interaction between Bumetanide and Hydrochlorothiazide-lisinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor electrolytes, renal function, weight and blood pressure, especially in the first weeks. Reduce diuretic doses if volume depletion develops.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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