Drug interactions
Bumetanide + Levomilnacipran
Severity: Moderate
Bumetanide and Levomilnacipran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics can cause hyponatremia, and SNRIs such as levomilnacipran are associated with SIADH-related hyponatremia. Used together, the risk of low sodium may be increased, particularly in older or volume-depleted patients.
What this interaction means in plain words
Bumetanide and Levomilnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Levomilnacipran belongs to Central Nervous System.
Why it happens
Additive effects on sodium balance: diuretic-induced renal sodium loss plus SNRI-associated inappropriate ADH secretion.
What to do
Check serum sodium at baseline and after starting or changing doses, especially in elderly patients. Stop or reduce the offending drug if symptomatic or significant hyponatremia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bumetanide
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Bumetanide with Levomilnacipran?
MediHelp rates the interaction as moderate. Bumetanide and Levomilnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loop diuretics can cause hyponatremia, and SNRIs such as levomilnacipran are associated with SIADH-related hyponatremia. Used together, the risk of low sodium may be increased, particularly in older or volume-depleted patients.
How serious is the interaction between Bumetanide and Levomilnacipran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum sodium at baseline and after starting or changing doses, especially in elderly patients. Stop or reduce the offending drug if symptomatic or significant hyponatremia develops.
What other medicines interact with Bumetanide?
MediHelp also lists interactions of Bumetanide with, for example, Amifostine, Amikacin, Captopril-hydrochlorothiazide. The full list is on the Bumetanide page.
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