Drug interactions
Bupropion + Gepirone
Severity: Moderate
Bupropion and Gepirone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gepirone is a serotonin 5-HT1A agonist antidepressant, and combination with other antidepressants may raise the risk of serotonin toxicity. Bupropion also inhibits CYP2D6 and its effect on gepirone exposure is not well established, while both lower seizure thresholds to some degree.
What this interaction means in plain words
Bupropion and Gepirone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion belongs to Central Nervous System; Gepirone belongs to Central Nervous System.
Why it happens
Additive serotonergic and monoaminergic effects, with possible pharmacokinetic effects via CYP inhibition.
What to do
Monitor for features of serotonin syndrome such as agitation, tremor, hyperreflexia and fever, especially at initiation and dose increases. Discontinue one or both agents if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Gepirone
- Clarithromycin + Gepirone Contraindicated
- Gepirone + Isocarboxazid Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Linezolid Contraindicated
- Gepirone + Phenelzine Contraindicated
Frequently asked questions
Can I take Bupropion with Gepirone?
MediHelp rates the interaction as moderate. Bupropion and Gepirone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gepirone is a serotonin 5-HT1A agonist antidepressant, and combination with other antidepressants may raise the risk of serotonin toxicity. Bupropion also inhibits CYP2D6 and its effect on gepirone exposure is not well established, while both lower seizure thresholds to some degree.
How serious is the interaction between Bupropion and Gepirone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for features of serotonin syndrome such as agitation, tremor, hyperreflexia and fever, especially at initiation and dose increases. Discontinue one or both agents if toxicity occurs.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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