Drug interactions
Bupropion + Loratadine
Severity: Minor
Bupropion and Loratadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion is a strong CYP2D6 inhibitor and loratadine's active metabolite desloratadine is formed partly via CYP2D6 and CYP3A4. Exposure to loratadine may rise slightly, but its wide safety margin makes clinical consequences unlikely.
What this interaction means in plain words
Bupropion and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bupropion belongs to Central Nervous System; Loratadine belongs to Respiratory.
Why it happens
Inhibition of CYP2D6-mediated metabolism of loratadine by bupropion and its metabolites.
What to do
No dose adjustment is needed; monitor for increased drowsiness or anticholinergic symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Bupropion with Loratadine?
MediHelp rates the interaction as minor. Bupropion and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bupropion is a strong CYP2D6 inhibitor and loratadine's active metabolite desloratadine is formed partly via CYP2D6 and CYP3A4. Exposure to loratadine may rise slightly, but its wide safety margin makes clinical consequences unlikely.
How serious is the interaction between Bupropion and Loratadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for increased drowsiness or anticholinergic symptoms.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
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