Drug interactions
Bupropion + Methamphetamine
Severity: Moderate
Bupropion and Methamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion inhibits CYP2D6, which may raise methamphetamine exposure, and both drugs are CNS stimulants. The combination can increase the risk of seizures, hypertension, tachycardia and agitation.
What this interaction means in plain words
Bupropion and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion belongs to Central Nervous System; Methamphetamine belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by bupropion plus additive stimulant effects and lowered seizure threshold.
What to do
Use the lowest effective doses of both and avoid in patients with seizure history. Monitor blood pressure, heart rate and neuropsychiatric effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Bupropion with Methamphetamine?
MediHelp rates the interaction as moderate. Bupropion and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bupropion inhibits CYP2D6, which may raise methamphetamine exposure, and both drugs are CNS stimulants. The combination can increase the risk of seizures, hypertension, tachycardia and agitation.
How serious is the interaction between Bupropion and Methamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses of both and avoid in patients with seizure history. Monitor blood pressure, heart rate and neuropsychiatric effects.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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