Drug interactions
Bupropion + Mirtazapine
Severity: Minor
Bupropion and Mirtazapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mirtazapine is partly metabolized by CYP2D6, so bupropion may modestly raise its levels. The effect is usually limited because other pathways (CYP3A4, CYP1A2) contribute to clearance.
What this interaction means in plain words
Bupropion and Mirtazapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bupropion belongs to Central Nervous System; Mirtazapine belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by bupropion modestly reduces mirtazapine clearance.
What to do
Monitor for increased sedation or other adverse effects and adjust mirtazapine dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Bupropion with Mirtazapine?
MediHelp rates the interaction as minor. Bupropion and Mirtazapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mirtazapine is partly metabolized by CYP2D6, so bupropion may modestly raise its levels. The effect is usually limited because other pathways (CYP3A4, CYP1A2) contribute to clearance.
How serious is the interaction between Bupropion and Mirtazapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation or other adverse effects and adjust mirtazapine dose if they occur.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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