Drug interactions
Bupropion + Ozanimod
Severity: Major
Bupropion and Ozanimod: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod's active metabolites inhibit MAO-B in vitro, and the labeling warns against combining it with drugs that raise norepinephrine or serotonin because of possible hypertensive crisis or serotonin syndrome. Bupropion inhibits dopamine and norepinephrine reuptake and can itself raise blood pressure. The risk is mainly predicted from mechanism.
What this interaction means in plain words
Bupropion and Ozanimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bupropion belongs to Central Nervous System; Ozanimod belongs to Central Nervous System.
Why it happens
Additive increase in noradrenergic and dopaminergic activity via reuptake inhibition (bupropion) and MAO-B inhibition by ozanimod metabolites.
What to do
Avoid the combination where feasible; if both are needed, monitor blood pressure and heart rate and watch for signs of serotonin toxicity or hypertensive reaction.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Bupropion with Ozanimod?
MediHelp rates the interaction as major. Bupropion and Ozanimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ozanimod's active metabolites inhibit MAO-B in vitro, and the labeling warns against combining it with drugs that raise norepinephrine or serotonin because of possible hypertensive crisis or serotonin syndrome. Bupropion inhibits dopamine and norepinephrine reuptake and can itself raise blood pressure. The risk is mainly predicted from mechanism.
How serious is the interaction between Bupropion and Ozanimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where feasible; if both are needed, monitor blood pressure and heart rate and watch for signs of serotonin toxicity or hypertensive reaction.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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