Drug interactions
Bupropion + Risperidone
Severity: Moderate
Bupropion and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone is converted by CYP2D6 to the equally active 9-hydroxyrisperidone, so bupropion raises parent drug levels while the active moiety changes less. Extrapyramidal symptoms and sedation may increase, and seizure threshold may be lowered further.
What this interaction means in plain words
Bupropion and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion belongs to Central Nervous System; Risperidone belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by bupropion alters risperidone metabolism, with additive lowering of seizure threshold.
What to do
Monitor for extrapyramidal symptoms, sedation and orthostasis, and reduce the risperidone dose if they occur. Use the lowest effective bupropion dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Bupropion with Risperidone?
MediHelp rates the interaction as moderate. Bupropion and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone is converted by CYP2D6 to the equally active 9-hydroxyrisperidone, so bupropion raises parent drug levels while the active moiety changes less. Extrapyramidal symptoms and sedation may increase, and seizure threshold may be lowered further.
How serious is the interaction between Bupropion and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, sedation and orthostasis, and reduce the risperidone dose if they occur. Use the lowest effective bupropion dose.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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