Drug interactions
Bupropion + Stiripentol
Severity: Moderate
Bupropion and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol affects CYP2B6 activity, so bupropion concentrations may change unpredictably, risking either toxicity or reduced effect. Stiripentol is also a CYP2D6 and CYP3A4 modulator, adding to uncertainty.
What this interaction means in plain words
Bupropion and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol inhibits and induces CYP2B6, altering bupropion metabolism.
What to do
Monitor for bupropion adverse effects (including seizures) and for loss of efficacy. Adjust the bupropion dose based on response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Bupropion with Stiripentol?
MediHelp rates the interaction as moderate. Bupropion and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol affects CYP2B6 activity, so bupropion concentrations may change unpredictably, risking either toxicity or reduced effect. Stiripentol is also a CYP2D6 and CYP3A4 modulator, adding to uncertainty.
How serious is the interaction between Bupropion and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bupropion adverse effects (including seizures) and for loss of efficacy. Adjust the bupropion dose based on response.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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