Drug interactions
Bupropion + Trazodone
Severity: Moderate
Bupropion and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion inhibits CYP2D6 and may alter trazodone's metabolite exposure, and both drugs can lower the seizure threshold. Serotonergic effects are possible. The combination is sometimes used but requires dose care.
What this interaction means in plain words
Bupropion and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Additive seizure-threshold lowering with possible metabolic effects on trazodone via CYP2D6.
What to do
Start low and titrate slowly. Monitor for seizures, sedation and serotonergic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Bupropion with Trazodone?
MediHelp rates the interaction as moderate. Bupropion and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bupropion inhibits CYP2D6 and may alter trazodone's metabolite exposure, and both drugs can lower the seizure threshold. Serotonergic effects are possible. The combination is sometimes used but requires dose care.
How serious is the interaction between Bupropion and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start low and titrate slowly. Monitor for seizures, sedation and serotonergic symptoms.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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