Drug interactions
Bupropion + Vortioxetine
Severity: Moderate
Bupropion and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion strongly inhibits CYP2D6, which is the main metabolic route of vortioxetine, producing substantially higher vortioxetine exposure. This increases adverse effects such as nausea and may add to serotonergic and seizure risk.
What this interaction means in plain words
Bupropion and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion belongs to Central Nervous System; Vortioxetine belongs to Central Nervous System.
Why it happens
Bupropion inhibits CYP2D6, increasing vortioxetine exposure.
What to do
Consider halving the vortioxetine dose when bupropion is started, and return to the usual dose if bupropion is stopped. Monitor for nausea and serotonergic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Bupropion with Vortioxetine?
MediHelp rates the interaction as moderate. Bupropion and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bupropion strongly inhibits CYP2D6, which is the main metabolic route of vortioxetine, producing substantially higher vortioxetine exposure. This increases adverse effects such as nausea and may add to serotonergic and seizure risk.
How serious is the interaction between Bupropion and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider halving the vortioxetine dose when bupropion is started, and return to the usual dose if bupropion is stopped. Monitor for nausea and serotonergic symptoms.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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