Drug interactions
Bupropion-naltrexone + Chloroquine
Severity: Moderate
Bupropion-naltrexone and Chloroquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion may raise chloroquine exposure, and both can lower seizure threshold or affect cardiac conduction. The clinical impact is uncertain but potentially relevant in vulnerable patients.
What this interaction means in plain words
Bupropion-naltrexone and Chloroquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion-naltrexone belongs to Miscellaneous; Chloroquine belongs to Anti Parasitic.
Why it happens
CYP2D6 inhibition by bupropion may reduce chloroquine metabolism, with additive seizure-threshold effects.
What to do
Monitor for adverse effects including neuropsychiatric symptoms and ECG changes; avoid in patients with seizure history.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Frequently asked questions
Can I take Bupropion-naltrexone with Chloroquine?
MediHelp rates the interaction as moderate. Bupropion-naltrexone and Chloroquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bupropion may raise chloroquine exposure, and both can lower seizure threshold or affect cardiac conduction. The clinical impact is uncertain but potentially relevant in vulnerable patients.
How serious is the interaction between Bupropion-naltrexone and Chloroquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects including neuropsychiatric symptoms and ECG changes; avoid in patients with seizure history.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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