Drug interactions
Bupropion-naltrexone + Digoxin
Severity: Minor
Bupropion-naltrexone and Digoxin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion may lower digoxin concentrations, possibly by affecting renal transporter-mediated elimination. The reduction in digoxin effect could reduce control of heart rate or heart failure symptoms. The evidence is limited and the mechanism is not firmly established.
What this interaction means in plain words
Bupropion-naltrexone and Digoxin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bupropion-naltrexone belongs to Miscellaneous; Digoxin belongs to Cardiovascular.
Why it happens
Proposed transporter-mediated change in digoxin disposition; the mechanism is not firmly established.
What to do
Check serum digoxin concentrations and heart rate when bupropion is started or stopped, and adjust the digoxin dose according to the results.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Bupropion-naltrexone with Digoxin?
MediHelp rates the interaction as minor. Bupropion-naltrexone and Digoxin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bupropion may lower digoxin concentrations, possibly by affecting renal transporter-mediated elimination. The reduction in digoxin effect could reduce control of heart rate or heart failure symptoms. The evidence is limited and the mechanism is not firmly established.
How serious is the interaction between Bupropion-naltrexone and Digoxin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum digoxin concentrations and heart rate when bupropion is started or stopped, and adjust the digoxin dose according to the results.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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