Drug interactions
Bupropion-naltrexone + Fenfluramine
Severity: Moderate
Bupropion-naltrexone and Fenfluramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine releases serotonin, and combination with other serotonergic or monoaminergic drugs may increase serotonin syndrome risk. Bupropion also has weak serotonergic involvement and lowers seizure threshold, a concern in epilepsy.
What this interaction means in plain words
Bupropion-naltrexone and Fenfluramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion-naltrexone belongs to Miscellaneous; Fenfluramine belongs to Central Nervous System.
Why it happens
Additive serotonergic and monoaminergic activity; bupropion also lowers the seizure threshold.
What to do
Monitor for agitation, tremor, hyperthermia and clonus, and for seizure frequency. Stop the agents if serotonin syndrome develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Bupropion-naltrexone with Fenfluramine?
MediHelp rates the interaction as moderate. Bupropion-naltrexone and Fenfluramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenfluramine releases serotonin, and combination with other serotonergic or monoaminergic drugs may increase serotonin syndrome risk. Bupropion also has weak serotonergic involvement and lowers seizure threshold, a concern in epilepsy.
How serious is the interaction between Bupropion-naltrexone and Fenfluramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperthermia and clonus, and for seizure frequency. Stop the agents if serotonin syndrome develops.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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