Drug interactions
Bupropion-naltrexone + Loratadine
Severity: Minor
Bupropion-naltrexone and Loratadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loratadine is metabolized partly by CYP2D6, so bupropion may modestly raise concentrations. Loratadine has a wide safety margin, so clinical effects are generally minor.
What this interaction means in plain words
Bupropion-naltrexone and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bupropion-naltrexone belongs to Miscellaneous; Loratadine belongs to Respiratory.
Why it happens
Bupropion inhibits CYP2D6, slightly reducing loratadine metabolism.
What to do
No dose change is usually required; watch for increased drowsiness or palpitations.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Frequently asked questions
Can I take Bupropion-naltrexone with Loratadine?
MediHelp rates the interaction as minor. Bupropion-naltrexone and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Loratadine is metabolized partly by CYP2D6, so bupropion may modestly raise concentrations. Loratadine has a wide safety margin, so clinical effects are generally minor.
How serious is the interaction between Bupropion-naltrexone and Loratadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required; watch for increased drowsiness or palpitations.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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