Drug interactions
Bupropion-naltrexone + Modafinil
Severity: Minor
Bupropion-naltrexone and Modafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil may induce some CYP enzymes and could alter bupropion metabolism, lowering parent drug levels while changing active metabolite concentrations. The clinical consequence is uncertain.
What this interaction means in plain words
Bupropion-naltrexone and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bupropion-naltrexone belongs to Miscellaneous; Modafinil belongs to Central Nervous System.
Why it happens
Possible enzyme induction by modafinil altering bupropion metabolism.
What to do
No routine adjustment is needed; monitor clinical response and tolerability, including insomnia and anxiety.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Modafinil
Frequently asked questions
Can I take Bupropion-naltrexone with Modafinil?
MediHelp rates the interaction as minor. Bupropion-naltrexone and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Modafinil may induce some CYP enzymes and could alter bupropion metabolism, lowering parent drug levels while changing active metabolite concentrations. The clinical consequence is uncertain.
How serious is the interaction between Bupropion-naltrexone and Modafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor clinical response and tolerability, including insomnia and anxiety.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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