Drug interactions
Buspirone + Metoclopramide
Severity: Moderate
Buspirone and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buspirone has dopaminergic activity, and the combination with metoclopramide has been associated with extrapyramidal symptoms and may be additive in effect. Metoclopramide may also oppose or alter dopamine-related responses.
What this interaction means in plain words
Buspirone and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buspirone belongs to Central Nervous System; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Pharmacodynamic interaction at central dopamine receptors; the exact mechanism is not fully established.
What to do
Monitor for movement disorders, restlessness and changes in anxiety control. Stop metoclopramide if extrapyramidal symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Buspirone with Metoclopramide?
MediHelp rates the interaction as moderate. Buspirone and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buspirone has dopaminergic activity, and the combination with metoclopramide has been associated with extrapyramidal symptoms and may be additive in effect. Metoclopramide may also oppose or alter dopamine-related responses.
How serious is the interaction between Buspirone and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for movement disorders, restlessness and changes in anxiety control. Stop metoclopramide if extrapyramidal symptoms develop.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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