Drug interactions
Buspirone + Tucatinib
Severity: Moderate
Buspirone and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits CYP3A4 and can increase exposure to buspirone, a sensitive CYP3A4 substrate. This may cause more sedation, dizziness and nausea.
What this interaction means in plain words
Buspirone and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buspirone belongs to Central Nervous System; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits CYP3A4, reducing buspirone clearance.
What to do
Reduce the buspirone dose and titrate by response while on tucatinib. Monitor for sedation and dizziness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Buspirone with Tucatinib?
MediHelp rates the interaction as moderate. Buspirone and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib inhibits CYP3A4 and can increase exposure to buspirone, a sensitive CYP3A4 substrate. This may cause more sedation, dizziness and nausea.
How serious is the interaction between Buspirone and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the buspirone dose and titrate by response while on tucatinib. Monitor for sedation and dizziness.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
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