Drug interactions
Cabazitaxel + Posaconazole
Severity: Major
Cabazitaxel and Posaconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cabazitaxel is cleared mainly by CYP3A4, and strong inhibitors increase its exposure. This can worsen neutropenia and other toxicities such as diarrhea.
What this interaction means in plain words
Cabazitaxel and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cabazitaxel belongs to Oncology; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole strongly inhibits CYP3A4, reducing cabazitaxel metabolism.
What to do
Avoid the combination. If unavoidable, consider a cabazitaxel dose reduction and monitor blood counts closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Cabazitaxel
Frequently asked questions
Can I take Cabazitaxel with Posaconazole?
MediHelp rates the interaction as major. Cabazitaxel and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cabazitaxel is cleared mainly by CYP3A4, and strong inhibitors increase its exposure. This can worsen neutropenia and other toxicities such as diarrhea.
How serious is the interaction between Cabazitaxel and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If unavoidable, consider a cabazitaxel dose reduction and monitor blood counts closely.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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