Drug interactions
Caffeine + Lisdexamfetamine
Severity: Moderate
Caffeine and Lisdexamfetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Caffeine is a CNS stimulant and adds to the stimulant and cardiovascular effects of amphetamines. This may cause tremor, insomnia, anxiety, palpitations and higher blood pressure.
What this interaction means in plain words
Caffeine and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Caffeine belongs to Miscellaneous; Lisdexamfetamine belongs to Central Nervous System.
Why it happens
Additive CNS stimulation and sympathomimetic effects from adenosine antagonism and amphetamine-induced catecholamine release.
What to do
Advise limiting caffeine intake, including energy drinks and supplements. Monitor heart rate, blood pressure and sleep.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Other interactions of Caffeine
- Caffeine + Ephedrine Major
- Caffeine + Fezolinetant Major
- Caffeine + Methylenedioxymethamphetamine Major
- Caffeine + Selegiline transdermal Major
- Adenosine + Caffeine Moderate
- Benzphetamine + Caffeine Moderate
Frequently asked questions
Can I take Caffeine with Lisdexamfetamine?
MediHelp rates the interaction as moderate. Caffeine and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Caffeine is a CNS stimulant and adds to the stimulant and cardiovascular effects of amphetamines. This may cause tremor, insomnia, anxiety, palpitations and higher blood pressure.
How serious is the interaction between Caffeine and Lisdexamfetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise limiting caffeine intake, including energy drinks and supplements. Monitor heart rate, blood pressure and sleep.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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