Drug interactions
Caffeine + Posaconazole
Severity: Minor
Caffeine and Posaconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole may slightly increase caffeine levels, but caffeine is mainly metabolised by CYP1A2 and posaconazole does not inhibit it appreciably. Clinically relevant effects are unlikely at usual intakes.
What this interaction means in plain words
Caffeine and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Caffeine belongs to Miscellaneous; Posaconazole belongs to Anti Fungals.
Why it happens
Possible minor inhibition of caffeine metabolism; the mechanism is not well established.
What to do
No action needed beyond counselling to limit very high caffeine intake if jitteriness or palpitations occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Caffeine
- Caffeine + Ephedrine Major
- Caffeine + Fezolinetant Major
- Caffeine + Methylenedioxymethamphetamine Major
- Caffeine + Selegiline transdermal Major
- Adenosine + Caffeine Moderate
- Benzphetamine + Caffeine Moderate
Frequently asked questions
Can I take Caffeine with Posaconazole?
MediHelp rates the interaction as minor. Caffeine and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Posaconazole may slightly increase caffeine levels, but caffeine is mainly metabolised by CYP1A2 and posaconazole does not inhibit it appreciably. Clinically relevant effects are unlikely at usual intakes.
How serious is the interaction between Caffeine and Posaconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action needed beyond counselling to limit very high caffeine intake if jitteriness or palpitations occur.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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