Drug interactions
Caffeine + Teriflunomide
Severity: Minor
Caffeine and Teriflunomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriflunomide is a weak inducer of CYP1A2, which can modestly raise clearance of CYP1A2 substrates such as caffeine. The result is a small reduction in caffeine exposure that is rarely meaningful.
What this interaction means in plain words
Caffeine and Teriflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Caffeine belongs to Miscellaneous; Teriflunomide belongs to Central Nervous System.
Why it happens
Weak induction of CYP1A2 by teriflunomide increases caffeine metabolism.
What to do
No routine action is needed; be aware that caffeine effects may be slightly reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Teriflunomide
Other interactions of Caffeine
- Caffeine + Ephedrine Major
- Caffeine + Fezolinetant Major
- Caffeine + Methylenedioxymethamphetamine Major
- Caffeine + Selegiline transdermal Major
- Adenosine + Caffeine Moderate
- Benzphetamine + Caffeine Moderate
Frequently asked questions
Can I take Caffeine with Teriflunomide?
MediHelp rates the interaction as minor. Caffeine and Teriflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Teriflunomide is a weak inducer of CYP1A2, which can modestly raise clearance of CYP1A2 substrates such as caffeine. The result is a small reduction in caffeine exposure that is rarely meaningful.
How serious is the interaction between Caffeine and Teriflunomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; be aware that caffeine effects may be slightly reduced.
What other medicines interact with Teriflunomide?
MediHelp also lists interactions of Teriflunomide with, for example, Ifosfamide, Lomustine, Amiodarone. The full list is on the Teriflunomide page.
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