Drug interactions
Calcifediol + Imatinib
Severity: Minor
Calcifediol and Imatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP3A4, which may alter the metabolism of vitamin D compounds and change calcifediol concentrations or its conversion to calcitriol. The clinical effect is uncertain, but calcium and PTH balance could shift.
What this interaction means in plain words
Calcifediol and Imatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Calcifediol belongs to Musculoskeletal; Imatinib belongs to Oncology.
Why it happens
CYP3A4 inhibition by imatinib may alter the metabolism of calcifediol and its conversion to active vitamin D.
What to do
Check serum calcium, 25-hydroxyvitamin D and intact PTH when imatinib is started or stopped. Adjust the calcifediol dose according to the results.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Calcifediol
- Amlodipine-hydrochlorothiazide-valsartan + Calcifediol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcifediol Moderate
- Amobarbital + Calcifediol Moderate
- Atenolol-chlorthalidone + Calcifediol Moderate
- Azilsartan-chlorthalidone + Calcifediol Moderate
- Calcifediol + Candesartan-hydrochlorothiazide Moderate
Frequently asked questions
Can I take Calcifediol with Imatinib?
MediHelp rates the interaction as minor. Calcifediol and Imatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Imatinib inhibits CYP3A4, which may alter the metabolism of vitamin D compounds and change calcifediol concentrations or its conversion to calcitriol. The clinical effect is uncertain, but calcium and PTH balance could shift.
How serious is the interaction between Calcifediol and Imatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum calcium, 25-hydroxyvitamin D and intact PTH when imatinib is started or stopped. Adjust the calcifediol dose according to the results.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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