Drug interactions
Calcifediol + Nicardipine
Severity: Minor
Calcifediol and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labeling for calcifediol cautions about CYP3A4 inhibitors altering vitamin D metabolism. Nicardipine is a weak CYP3A4 inhibitor, so any effect on calcifediol levels or conversion to calcitriol is likely small and not well documented.
What this interaction means in plain words
Calcifediol and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Calcifediol belongs to Musculoskeletal; Nicardipine belongs to Cardiovascular.
Why it happens
Possible inhibition of CYP3A4 and related vitamin D hydroxylases, altering calcifediol disposition.
What to do
No routine dose change is needed. Check serum calcium, 25-hydroxyvitamin D and PTH if nicardipine is started or stopped in patients on calcifediol.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Other interactions of Calcifediol
- Amlodipine-hydrochlorothiazide-valsartan + Calcifediol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcifediol Moderate
- Amobarbital + Calcifediol Moderate
- Atenolol-chlorthalidone + Calcifediol Moderate
- Azilsartan-chlorthalidone + Calcifediol Moderate
- Calcifediol + Candesartan-hydrochlorothiazide Moderate
Frequently asked questions
Can I take Calcifediol with Nicardipine?
MediHelp rates the interaction as minor. Calcifediol and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Labeling for calcifediol cautions about CYP3A4 inhibitors altering vitamin D metabolism. Nicardipine is a weak CYP3A4 inhibitor, so any effect on calcifediol levels or conversion to calcitriol is likely small and not well documented.
How serious is the interaction between Calcifediol and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Check serum calcium, 25-hydroxyvitamin D and PTH if nicardipine is started or stopped in patients on calcifediol.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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