Drug interactions
Calcitriol + Hydrochlorothiazide
Severity: Moderate
Calcitriol and Hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides reduce urinary calcium excretion, and calcitriol raises calcium absorption and levels, so hypercalcemia can result. The risk is greater with oral or injectable calcitriol, high doses or renal impairment; topical use carries less risk.
What this interaction means in plain words
Calcitriol and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcitriol belongs to Musculoskeletal; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Thiazides increase renal calcium reabsorption while calcitriol increases intestinal calcium absorption, producing additive rises in serum calcium.
What to do
Monitor serum calcium, especially with systemic calcitriol, and reduce the calcitriol dose or stop the thiazide if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide
Other interactions of Calcitriol
- Amlodipine-hydrochlorothiazide-valsartan + Calcitriol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcitriol Moderate
- Amobarbital + Calcitriol Moderate
- Apalutamide + Calcitriol Moderate
- Atazanavir + Calcitriol Moderate
- Atenolol-chlorthalidone + Calcitriol Moderate
Frequently asked questions
Can I take Calcitriol with Hydrochlorothiazide?
MediHelp rates the interaction as moderate. Calcitriol and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides reduce urinary calcium excretion, and calcitriol raises calcium absorption and levels, so hypercalcemia can result. The risk is greater with oral or injectable calcitriol, high doses or renal impairment; topical use carries less risk.
How serious is the interaction between Calcitriol and Hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium, especially with systemic calcitriol, and reduce the calcitriol dose or stop the thiazide if hypercalcemia develops.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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