Drug interactions
Calcitriol + Idelalisib
Severity: Moderate
Calcitriol and Idelalisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib strongly inhibits CYP3A, which contributes to the breakdown of calcitriol. Calcitriol exposure may rise, increasing the likelihood of hypercalcemia and hypercalciuria.
What this interaction means in plain words
Calcitriol and Idelalisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcitriol belongs to Musculoskeletal; Idelalisib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated catabolism of calcitriol (24-hydroxylation) by idelalisib.
What to do
Monitor serum calcium and phosphate after starting or stopping idelalisib, and reduce the calcitriol dose if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcitriol
- Amlodipine-hydrochlorothiazide-valsartan + Calcitriol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcitriol Moderate
- Amobarbital + Calcitriol Moderate
- Apalutamide + Calcitriol Moderate
- Atazanavir + Calcitriol Moderate
- Atenolol-chlorthalidone + Calcitriol Moderate
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Calcitriol with Idelalisib?
MediHelp rates the interaction as moderate. Calcitriol and Idelalisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idelalisib strongly inhibits CYP3A, which contributes to the breakdown of calcitriol. Calcitriol exposure may rise, increasing the likelihood of hypercalcemia and hypercalciuria.
How serious is the interaction between Calcitriol and Idelalisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and phosphate after starting or stopping idelalisib, and reduce the calcitriol dose if hypercalcemia develops.
What other medicines interact with Calcitriol?
MediHelp also lists interactions of Calcitriol with, for example, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide, Amobarbital. The full list is on the Calcitriol page.
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