Drug interactions
Calcitriol + Linagliptin
Severity: Minor
Calcitriol and Linagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
If calcitriol weakly induces CYP3A4, linagliptin exposure would be expected to fall, not rise. Linagliptin is mainly eliminated unchanged, and any effect from calcitriol is expected to be negligible.
What this interaction means in plain words
Calcitriol and Linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Calcitriol belongs to Musculoskeletal; Linagliptin belongs to Endocrine.
Why it happens
Theoretical weak CYP3A4 induction by calcitriol; linagliptin has limited metabolism.
What to do
No dose adjustment is needed. Monitor glycemic control as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Calcitriol
- Amlodipine-hydrochlorothiazide-valsartan + Calcitriol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcitriol Moderate
- Amobarbital + Calcitriol Moderate
- Apalutamide + Calcitriol Moderate
- Atazanavir + Calcitriol Moderate
- Atenolol-chlorthalidone + Calcitriol Moderate
Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Frequently asked questions
Can I take Calcitriol with Linagliptin?
MediHelp rates the interaction as minor. Calcitriol and Linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. If calcitriol weakly induces CYP3A4, linagliptin exposure would be expected to fall, not rise. Linagliptin is mainly eliminated unchanged, and any effect from calcitriol is expected to be negligible.
How serious is the interaction between Calcitriol and Linagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor glycemic control as usual.
What other medicines interact with Calcitriol?
MediHelp also lists interactions of Calcitriol with, for example, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide, Amobarbital. The full list is on the Calcitriol page.
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