Drug interactions
Calcitriol + Stiripentol
Severity: Minor
Calcitriol and Stiripentol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol both inhibits and induces CYP3A4, so calcitriol exposure may rise or fall. The clinical effect is uncertain.
What this interaction means in plain words
Calcitriol and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Calcitriol belongs to Musculoskeletal; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol has mixed inhibitory and inducing effects on CYP3A4, altering calcitriol metabolism.
What to do
Monitor serum calcium and PTH after starting or stopping stiripentol and adjust the calcitriol dose as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Calcitriol
- Amlodipine-hydrochlorothiazide-valsartan + Calcitriol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcitriol Moderate
- Amobarbital + Calcitriol Moderate
- Apalutamide + Calcitriol Moderate
- Atazanavir + Calcitriol Moderate
- Atenolol-chlorthalidone + Calcitriol Moderate
Other interactions of Stiripentol
Frequently asked questions
Can I take Calcitriol with Stiripentol?
MediHelp rates the interaction as minor. Calcitriol and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stiripentol both inhibits and induces CYP3A4, so calcitriol exposure may rise or fall. The clinical effect is uncertain.
How serious is the interaction between Calcitriol and Stiripentol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and PTH after starting or stopping stiripentol and adjust the calcitriol dose as needed.
What other medicines interact with Calcitriol?
MediHelp also lists interactions of Calcitriol with, for example, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide, Amobarbital. The full list is on the Calcitriol page.
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